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Yet, as with NRF2, tumor contexts complicate interpretation: HO-1 is overexpressed in some cancers, including HCC, where it actively supports tumor progression by enhancing survival via mechanisms such as increasing cancer cell proliferation, conferring resistance to chemo- and radiotherapy, and promoting angiogenesis, as indicated by its strong correlation with VEGF expression and microvascular invasion

563 Monitoring and considerations include dose titration, initiating medications at low doses and gradually increasing to the maximum tolerated dose while monitoring efficacy and adverse effects

Kirti (2014)

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